%0 Journal Article
%T Identifying the common interaction networks of amoeboid motility and cancer cell metastasis
%A Ahmed H. Zeitoun
%A Shady S. Ibrahim
%A Christoph P. Bagowski
%J Network Biology
%D 2012
%I International Academy of Ecology and Environmental Sciences
%X The recently analyzed genome of Naegleria gruberi, a free-living amoeboflagellate of the Heterolobosea clade, revealed a remarkably complex ancestral eukaryote with a rich repertoire of cytoskeletal-, motility- and signaling-genes. This protist, which diverged from other eukaryotic lineages over a billion years ago, possesses the ability for both amoeboid and flagellar motility. In a phylogenomic comparison of two free living eukaryotes with large proteomic datasets of three metastatic tumour entities (malignant melanoma, breast- and prostate-carcinoma), we find common proteins with potential importance for cell motility and cancer cell metastasis. To identify the underlying signaling modules, we constructed for each tumour type a protein-protein interaction network including these common proteins. The connectivity within this interactome revealed specific interactions and pathways which constitute prospective points of intervention for novel anti-metastatic tumour therapies.
%K movement
%K invasion
%K protein interaction network
%K PDZ domain
%K Proteome
%K cancer
%K tumour
%K interactome
%K prostate
%K breast carcinoma
%K metastatic behaviour
%U http://www.iaees.org/publications/journals/nb/articles/2012-2(2)/identifying-the-common-interaction-networks.pdf