%0 Journal Article
%T Negative double stranded DNA and anti-Smith antibodies in lupus nephritis
%A Gagangeet Sandhu
%A Anip Bansal
%A Aditi Ranade
%A Ritu Aggarwal
%J Nephrology Reviews
%D 2012
%I 
%R 10.4081/nr.2012.e13
%X Systemic lupus erythematosus (SLE) is an autoimmune disease in which auto-antibodies are generated against a variety of intracellular antigens. Anti-Smith (Sm) and anti-double stranded DNA (dsDNA) antibodies in particular are considered to be nephritogenic and their role and correlation with lupus nephritis (LN) has been well established. We present here a case in which the patient had diffuse proliferative full house severe LN, yet negative ds-DNA and anti-Sm antibodies. Although extremely rare, a few subsets of patients with drug-hepatitis C virus antibody, and HIV antibody Our patient was a 29-year old African-American female with no significant past medical history who presented to the emergency department with a one month history of generalized weakness, frequent tiredness and excessive vaginal bleeding. Her home medications included aspirin and recently discontinued depot medroxyprogesterone acetate injections. induced LN (hydralazine) have been described in the literature to have negative dsDNA and anti-Sm antibodies on serological screening. Our patient, however, had no evidence of drug induced LN. On further review, and similar to our case, we found only 6 additional well documented cases of non-drug induced severe LN with negative dsDNA antibodies.
%K negative double stranded DNA
%K anti-Smith antibodies
%K lupus nephritis
%U http://www.pagepress.org/journals/index.php/nr/article/view/4103