%0 Journal Article
%T Advanced Corneal Cross-Linking System with Fluorescence Dosimetry
%A Marc D. Friedman
%A Radha Pertaub
%A David Usher
%A Evan Sherr
%A Pavel Kamaev
%A David Muller
%J Journal of Ophthalmology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/303459
%X Purpose. This paper describes an advanced system that combines corneal cross-linking with riboflavin with fluorescence dosimetry, the ability to measure riboflavin diffusion within the cornea both before and during UVA treatment. Methods and Results. A corneal cross-linking system utilizing a digital micromirror device (DMD) was assembled and used to measure diffusion coefficients of 0.1% riboflavin in 20% dextran in porcine eyes. A value of (3.3¡À0.2)¡Á10£¿7 cm2/s was obtained for the stroma. Diffusion coefficients for the transepithelial formulation of 0.1% riboflavin in 0.44% saline and 0.02% BAK were also measured to be 4.7¡À0.3¡Á10£¿8 cm2/s for epithelium only and (4.6¡À0.4)¡Á10£¿7 cm2/s for stroma only. Riboflavin consumption during a UVA treatment was also demonstrated. Conclusion. A new advanced corneal cross-linking system with fluorescence dosimetry of riboflavin has been demonstrated. It is hoped that this method may play a significant role in determining the underlying mechanisms of corneal cross-linking and assist with the development of additional riboflavin formulations. Moreover, dosimetry may prove valuable in providing a method to account for the biological differences between individuals, potentially informing cornea-specific UVA treatment doses in real time.
%U http://www.hindawi.com/journals/jop/2012/303459/