%0 Journal Article
%T Synthesis of 3-benzyloxyl-17-maleyloxy-16, 17-secoestra- 1, 3, 5 (10)-triene-16-nitrile - Sinteza 3-benziloksi-17-maleiloksi- 16, 17-sekoestra-1, 3, 5 (10)-trien-16-nitrila
%A Jovanovi£¿-£¿anta Suzana S.
%A Gaborov Sanja L.
%A Petrovi£¿ Julijana A.
%J Zbornik Matice Srpske za Prirodne Nauke
%D 2002
%I Matica srpska, Novi Sad
%R 10.2298/zmspn0201005j
%X Under the conditions of Beckmann fragmentation reaction 3-benzyloxy-17(-hydroxyestra-1, 3, 5, (10)-triene-16-one oxime (2) gave the D-seco derivative 3. Sodium borohydride reduction of this compound afforded 3-benzyloxy-17-hydroxy-16, 17-secoestra-1, 3, 5 (10)-triene-16-nitrile (4). The esterification of seco-cyanoalcohol 4 was achieved by action of maleic acid anhydride in dry pyridine, yielding 3-benzyloxy-17-maleyloxy-16 17-secoestra-1, 3, 5 (10)-triene-16-nitrile (5).
%K steroids
%K 16
%K 17-seco-estrone derivatives
%K synthesis
%K Beckmann fragmentation
%K reaction
%K esterification
%K hemiesters
%U http://www.doiserbia.nb.rs/img/doi/0352-4906/2002/0352-49060201005J.pdf