%0 Journal Article
%T Chemical Stability of Hydrocortisone in Topical Preparation in Proprietary VersaProTM Cream Base
%A Arindam Basu Sarkar
%A Richard Dudley
%A Srikumaran Melethil
%A Jonathon Speidel
%J INNOVATIONS in Pharmacy
%D 2011
%I University of Minnesota College of Pharmacy
%X The United States Pharmacopeia-National Formulary (USP-NF) suggests beyond use dating ((BUD) for compounded topicalpreparations containing active pharmaceutical ingredients (API) [1]. The beyond the use dates of the preparations are based on theconservative and empirical guidelines of USP 795. Hydrocortisone (HC) content compounded in the VersaPro  base cream wasquantified using a HPLC method at time zero and after 30 and 60 days of storage at both room temperature and 4¡æ. The analysissuggests that the compounded preparations retain > 95% of the stated initial potency of HC regardless of storage conditions. ThusHC creams prepared in VersaPro  cream base can be safely assigned a beyond the use date of two months when stored at roomtemperature.
%U http://www.pharmacy.umn.edu/innovations/prod/groups/cop/@pub/@cop/@innov/documents/article/cop_article_349920.pdf