%0 Journal Article
%T ANTIOXIDANT, ANTI-INFLAMMATORY AND DIABETES RELATED ENZYME INHIBITION PROPERTIES OF LEAVES EXTRACT FROM SELECTED VARIETIES OF PHOENYX DACTYLIFERA L.
%A Laouini Salah Eddine
%J Innovare Journal of Life Science
%D 2013
%I Innovare Academic Sciences
%X Objective: to investigate the antioxidant, anti-inflammatory, and antidiabetic activities of ethanolic leaves extracts of three selected varieties of Phoenyx dactylifera L. namely: ¡°Ghars¡±, ¡°Deglet Nour¡± and ¡°Hamraya¡±. Methods: The assessment of the antioxidant potential of crude leaves extracts, using superoxide anions inhibition, DPPH and total antioxidant activity essays, was carried out. Furthermore, the anti-inflammatory properties of the extracts were determined by measuring the inhibition of nitric oxide (NO) production. Moreover, the antidiabetic effect was evaluated by inhibition of ¦Á-amylase and ¦Á-glucosidase enzymes. The total phenolic content measured by Folin-ciocalteu method was as well conducted. Results: The raw leaves extracts of the selected varieties was found to contain a high content of total phenolic content (342.45 mg GAE/ gDW for GE) and therefore exhibited a higher antioxidant activity and inhibitory effect of radicals scavenging activity against DPPH and superoxide anion (IC50=7.44 ¦Ìg/mL and 39.11 ¦Ìg/mL respectively). The three varieties exhibited significant anti-inflammatory effects using in-vitro inhibition of NO (IC50=240.28 ¦Ìg/mL for GE). The extracts also displayed high inhibition actions against ¦Á-amylase. Conclusion: the results suggest that the leaves of the three selected varieties of Phoenyx dactylifera can be considered as a good source of natural antioxidant and anti-inflammation drugs as well as potent antidiabetic medicine.
%U http://innovareacademics.in/journals/index.php/ijls/article/view/26