%0 Journal Article
%T The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats
%A Ziya Fallah-Mohammadi
%A Mojtaba Ebrahimzadeh
%A Akbar Hajizadeh-Moghaddam
%J Zahedan Journal of Research in Medical Sciences
%D 2013
%I Zahedan University of Medical Sciences
%X Background: Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan. Materials and Methods: 28 male rats weight 185¡À1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal. Results: 6 weeks of voluntary wheel running decreased the cortex A¦Â1-42 in T and DT groups. A¦Â1-42 levels significantly decreased in the T and DT in compare with C and CD (p<0.001), respectively. Also A¦Â1-42 levels significantly increased in the CD in compare with C (p<0.001).Conclusion: voluntary exercise had positive effects on decreasing of A¦Â1-42 levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes.
%K A¦Â1-42
%K Voluntary wheel running
%K Rats
%U http://www.zjrms.ir/browse.php?a_id=2049&sid=1&slc_lang=en