%0 Journal Article
%T Shiga Toxin Producing E. coli a?กฐ An Emerging Pathogen A Review
%A Lali Growther
%A Dr.Niren Andrew
%J World Journal of Science and Technology
%D 2011
%I 
%X Shiga toxin producing E. coli (STEC), a newly emerged pathogen that has been the focus of immense international research, is often associated with large epidemic outbreaks as well as the Hemolytic Uremic Syndrome(HUS), the leading cause of acute renal failure in children. STEC are a global problem, and more than 60 serotypes have been associated with human disease. A variety of foods have been identified as vehicles of STEC associated illness. The pathogenesis of STEC is multifactorial and involves several levels of interaction between the bacterium and the host. After ingestion, STEC colonize enterocytes of the large bowel with a characteristic attaching and effacing pathology, which is mediated by components of a type III secretion apparatus encoded by the LEE pathogenecity island. Two different types of shiga toxins produced by this organism enters the renal glomeruli and other organs through blood causing the pathophysiological changes that result in HUS. Specific therapeutic strategies are presently not available. The recent sequencing of the genome of epidemic strain of E. coli O157 strains offers a unique resource that will help to identify additional virulence genes. These research efforts in turn, should lead to development of new potent and cost effective therapies or vaccines. This brief review of the literature discusses the major outbreaks, sources, and pathogenesis of STEC disease, published in the past few years.
%K STEC
%K E.coli
%U http://worldjournalofscience.com/index.php/wjst/article/view/7370