%0 Journal Article
%T Cochleo-vestibular clinical findings among drug resistant Tuberculosis Patients on therapy-a pilot study
%A Lebogang Ramma
%A Titus S Ibekwe
%J International Archives of Medicine
%D 2012
%I BioMed Central
%R 10.1186/1755-7682-5-3
%X A cross-sectional study of adult MDR and XDR-TB patients was conducted in a general hospital in Cape-Town-South-Africa. Ethical approval was secured and all consenting patients administered with pretested and validated questionnaire under the guidance of International Classification of Functioning, Disability and Health(ICF) Checklist-version-2.1a. Audiometric evaluation included: Otoscopy, Diagnostic Audiometry and Tympanometry. The data analyses were done with SPSS version 16, Chi-square and StatCalc-7.Fifty-three adults, ages 18-60 (mean-33 years) comprising 26 males and 27 females participated in the study. Hospital stay duration varied from 1-18 months (mean-6 months) and all were on anti-Koch's second line drugs (regimen 2). MDR TB group were 45(85%) and XDR 8(15%). Vertigo was the most common vestibular symptoms, 24(45%) whereas, tinnitus 23(42%) and hearing loss 13(25%) were most frequent auditory complaints. Bilateral sensorineural hearing losses of varying degrees were confirmed in 23(47%).There was no association between gender and age with hearing loss [¦Ö2 (P = 0.16, £¿ = 0.05) and (p = 0.13, £¿ = 0.05)]. Furthermore, MDR and XTR TB groups [20/42 Vs 3/8; Z = 0.46 and P = 0.64], showed no difference in pattern of the hearing losses.A multi-disciplinary close surveillance of MDR and XDR TB patients on therapy is imperative. Finally, researches into therapeutic trials on antidotes and potent safer substitutes for aminoglycosides in the management are recommended.Following the advent of HIV-AIDS in 1981 there has been the explosion of opportunistic infections and global resurgence of diseases, prominent among which is tuberculosis (TB). The control of this disease especially in the developing world has suffered a great set back following resistance to conventional regimen for treatment of TB. As a result, the prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis particularly in Africa has been on the rise. Meyer and McAdam i
%K Multidrug resistance
%K Extreme drug resistance
%K Aminoglycosides
%K ototoxicity
%U http://www.intarchmed.com/content/5/1/3