%0 Journal Article %T Interactions between the immune system and bone %A Patrizia DĄŻAmelio %A Giorgia Fornelli %A Ilaria Roato %A Giovanni Carlo Isaia %J World Journal of Orthopedics %D 2011 %I Baishideng Publishing Group Co. Limited %R 10.5312/wjo.v2.i3.25 %X The relationship between the immune system, estrogen deficiency and bone loss is an intriguing and, as yet, unexplained challenge of the past two decades. Here we summarize the evidence that links immune cells, inflammation, cytokine production and osteoclast formation and activity with particular regard to humans. %K Osteoclast %K T cells %K Cytokines %K Osteoporosis %K Immune system %K Menopause %U http://www.wjgnet.com/2218-5836/full/v2/i3/25.htm