%0 Journal Article
%T Immune regulatory properties of multipotent mesenchymal stromal cells: Where do we stand?
%A ¨ºnio Jos¨¦ Bassi
%A Carlos Alberto Mayora Aita
%A Niels Olsen Saraiva Camara
%J World Journal of Stem Cells
%D 2011
%I Baishideng Publishing Group Co. Limited
%X Multipotent mesenchymal stromal cells (MSC) can be isolated and efficiently expanded from almost every single body tissue and have the ability of self-renewal and differentiation into various mesodermal cell lineages. Moreover, these cells are considered immunologically privileged, related to a lack of surface expression of costimulatory molecules required for complete T cell activation. Recently, it has been observed that MSC are capable of suppressing the immune response by inhibiting the maturation of dendritic cells and suppressing the function of T lymphocytes, B lymphocytes and natural killer cells in autoimmune and inflammatory diseases as a new strategy for immunosuppression. The understanding of immune regulation mechanisms by MSC is necessary for their use as immunotherapy in clinical applications for several diseases.
%K Immunosuppression
%K Mesenchymal stem cell
%K Immune system
%K Inflammation
%K Autoimmune disease
%U http://www.wjgnet.com/1948-0210/full/v3/i1/1.htm