%0 Journal Article %T Methods for the guideline-based development of quality indicators--a systematic review %A Thomas K£¿tter %A Eva Blozik %A Martin Scherer %J Implementation Science %D 2012 %I BioMed Central %R 10.1186/1748-5908-7-21 %X We systematically searched medical literature databases (Medline, EMBASE, and CINAHL) and grey literature. Two researchers selected publications reporting methodological approaches to guideline-based QI development. In order to describe and compare methodological approaches used in these publications, we extracted detailed information on common steps of guideline-based QI development (topic selection, guideline selection, extraction of recommendations, QI selection, practice test, and implementation) to predesigned extraction tables.From 8,697 hits in the database search and several grey literature documents, we selected 48 relevant references. The studies were of heterogeneous type and quality. We found no randomized controlled trial or other studies comparing the ability of different methodological approaches to guideline-based development to generate high-quality QIs. The relevant publications featured a wide variety of methodological approaches to guideline-based QI development, especially regarding guideline selection and extraction of recommendations. Only a few studies reported patient involvement.Further research is needed to determine which elements of the methodological approaches identified, described, and compared in this review are best suited to constitute a gold standard for guideline-based QI development. For this research, we provide a comprehensive groundwork.According to the definition of the Institute of Medicine (1990), quality of care is the "degree to which health services for individuals and populations increase the likelihood of desired health outcomes and are consistent with current professional knowledge" [1,2]. Increasingly, quality indicators (QIs) are employed to assess and improve the quality of care in many healthcare settings [1,3-5]. QIs are measurable items referring to structures, processes, and outcomes of care [6]. They imply a judgment on the quality of care provided. However, the interpretation of such performance assessments %U http://www.implementationscience.com/content/7/1/21