%0 Journal Article
%T Mesalamine induced symptom exacerbation of ulcerative colitis: Case report and brief discussion
%A Maneesh Kumar Gupta
%A Scott Pollack
%A John J Hutchings
%J World Journal of Gastrointestinal Pharmacology and Therapeutics
%D 2010
%I Baishideng Publishing Group Co. Limited
%X This paper describes a rare case in which the oral administration of mesalamine resulted in the exacerbation of ulcerative colitis (UC) in a patient who was previously responsive to mesalamine and whose colitis had been in remission for eight years. Mesalamine and other 5-aminosalicylic acid compounds are the mainstay of treatment for UC; however up to 8% of patients are unable to take the medications due to intolerance or hypersensitivity reactions. Common drug reactions are fever, nausea, diarrhea and abdominal pain; however, exacerbation of UC has rarely been reported. This study highlights the importance of ruling out mesalamine as the causative agent in cases of UC exacerbations.
%K Mesalamine
%K Exacerbation
%K Ulcerative colitis
%K Inflammation
%K Adverse drug reaction
%U http://www.wjgnet.com/2150-5349/full/v1/i6/132.htm