%0 Journal Article
%T Endothelin and neonatal capsaicin regulate gastric resistance to injury in BDL rats
%A Paula RS Camara
%A Gerson JN Ferraz
%A Licio A Velloso
%A Jos¨¦ Murilo R Zeitune
%J World Journal of Gastrointestinal Pathophysiology
%D 2012
%I Baishideng Publishing Group Co. Limited
%R 10.4291/wjgp.v3.i4.85
%X AIM: To investigate the relationship between primary afferent neurons, endothelin (ET) and the role of its receptors on ethanol-induced gastric damage in cirrhotic rats. METHODS: Cirrhosis and portal hypertension were induced in rats by bile duct ligation (BDL) while controls had a sham operation. The association between ET and afferent neurons on the gastric mucosa was evaluated by capsaicin treatment in newborn rats, the use of ET agonists or antagonists, gastric ET-1 and -3 mRNA and synthetic capacity. Ethanol-induced damage was assessed using ex vivo gastric chamber experiments. Gastric blood flow was measured by laser-Doppler flowmetry. RESULTS: ET-3 and an ETB receptor antagonist significantly reduced the extent of ethanol-induced gastric damage in BDL rats. Gastric ET-1 and -3 levels were 30% higher in BDL rats compared to control rats. Capsaicin treatment restored the gastric resistance and blood flow responses to topical application of ethanol in BDL rats and ET-1 and -3 production to levels observed in controls. CONCLUSION: Our results suggest that the reduced resistance of the gastric mucosa of cirrhotic rats to ethanol-induced injury is a phenomenon modulated by ET through the ETB receptor and by sensory afferent neurons.
%K Endothelins
%K Tachykinins
%K Portal hypertension
%K Gastropathy
%K Cirrhosis
%U http://www.wjgnet.com/2150-5330/full/v3/i4/85.htm