%0 Journal Article
%T Relationship between quality of life and clinical status in patients with gastrointestinal cancer Relaci¨®n entre calidad de vida y estadio cl¨ªnico en pacientes con c¨¢ncer gastrointestinal
%A Ricardo S¨¢nchez
%A Fabio Alexander-Sierra
%A Ricardo Oliveros
%J Revista Espa£¿ola de Enfermedades Digestivas
%D 2012
%I The Spanish Society of Digestive Pathology
%X Background: previous studies with patients having cancer have shown that quality of life scores depend on the clinical stage of the disease (the more advanced the disease, the worst quality of life). Methods: in a prospective study we studied 317 patients with gastric or colorectal cancer attending the Instituto Nacional de Cancerolog¨ªa between 2010 and 2011; the patients completed the EORTC QLQ-C30 before receiving treatment. This instrument measures quality of life in 15 domains. Scores of each domain were compared according to tumor stage. Differential Item Functioning was measured across neoplasm staging and tumor localization. Results: 145 patients (45.7%) were diagnosed with colorectal cancer. According to clinical staging, differences in quality of life scores were observed in 4 of 15 domains (physical and social functioning, anorexia). Most of the differences in quality of life domains depended on tumor localization (patients with colorectal cancer had the highest scores in quality of life) and sex (women reported better scores). These differences seemed to be independent of item properties. The construct was more adequately measured with items that explore the construct using a general approach. Conclusion: in this group of patients with colorectal and gastric cancer quality of life scores were more related with tumor localization than with clinical stage. Introducci¨®n: la calidad de vida de pacientes con c¨¢ncer var¨ªa seg¨²n el estadio cl¨ªnico de la enfermedad, siendo peor en estadios avanzados. M¨¦todos: estudio prospectivo en el que se evaluaron 317 pacientes con c¨¢ncer colorrectal o g¨¢strico que asistieron al Instituto Nacional de Cancerolog¨ªa durante los a os 2010 y 2011 y que no hab¨ªan iniciado tratamiento. Se utiliz¨® el cuestionario EORTC QLQ C-30, un instrumento que mide calidad de vida en 15 dominios. Se compararon las puntuaciones para cada dominio seg¨²n el estadio tumoral. Adicionalmente se realiz¨® un an¨¢lisis de funcionamiento diferencial de ¨ªtems para establecer si las diferencias encontradas correspond¨ªan a propiedades del instrumento o de la muestra de pacientes. Resultados: 145 pacientes (45,7%) tuvieron diagn¨®stico de c¨¢ncer de colon. Dependiendo del estadio cl¨ªnico se encontraron diferencias en los niveles de calidad de vida solo en tres de los 15 dominios (funcionamiento f¨ªsico, funcionamiento social y anorexia). Las principales diferencias en los dominios del constructo dependieron de la localizaci¨®n del tumor (los pacientes con c¨¢ncer colorrectal presentaron mejor calidad de vida) y del sexo (las mujeres reportaron mejor calid
%K Calidad de vida
%K Evaluaci¨®n en salud
%K Neoplasias
%K Grupos por edad
%K Quality of life
%K Outcome assessment (Health Care)
%K Neoplasms
%K Age groups
%U http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082012001100006