%0 Journal Article
%T Adult type granulosa cell tumor - morphological features
%A Ioana Buda
%A Raluca Balan
%A Crauciuc Eduard
%A Ovidiu Toma
%J Analele £¿tiin£¿ifice Ale Universit£¿£¿ii Alexandru Ioan Cuza din Ia£¿i,Sectiunea II A : Genetica si Biologie Moleculara
%D 2008
%I Alexandru Ioan Cuza University of Iasi
%X Adult granulosa cell tumors (AGCT) account for approximately 1-2% of all ovarian tumors and 95% of all GCT. They occur more often in postmenopausal women, with a peak incidence between 50 and 55 years. Nine cases of AGCT were diagnosed in the Clinical Hospital of Obstetrics and Gynecology Iasi, in a 10 years period. The age of the patients ranged between 35 and 67 years, 4 of them (44.44%) being postmenopausal. The macroscopical appearance showed that all were unilateral tumors ¨C 6 of them (66.66%) solid and 3 cystic (33.33%). After paraffin-embedding and usual stainings, we observed the granulosa cells as small, cuboidal to polygonal cells, arranged in anastomosing cords, and gland-like structures filled with an acidophilic material recalling immature follicles (Call-Exner bodies). Two tumors presented microfollicular and macrofollicular patterns. Three tumors (33.33%) presented also a thecoma component formed by sheets of cuboidal to polygonal cells (specifically called granulosa-theca cell tumors). In two of them both granulosa and theca cells presented aspects of luteinization (luteinized granulosa-theca cell tumors). Only one tumor (11.11%) was associated with simple hyperplasia of the endometrium (suggesting an active endocrine tumor). One tumor was associated with an ovarian endometrioid adenocarcinoma. Although considered as benign tumors, only 5-25% of them being malignant, with an indolent course and only local recurrences, in the reported cases the tumors were mainly malignant (66.66%), two of them being highly aggressive, as vascular invasion was noted, and one of them was also advanced, with histologically confirmed implants of abdominal peritoneal surfaces.
%U http://www.gbm.bio.uaic.ro/index.php/gbm/article/view/724