%0 Journal Article
%T Colorectal cancer risk in Crohns disease
%A Hugh James Freeman
%J World Journal of Gastroenterology
%D 2008
%I Baishideng Publishing Group Co. Limited
%X There is recognized increased risk for colorectal cancer in patients with inflammatory bowel disease, particularly in long-standing and extensive ulcerative colitis. There also appears to be an increased rate of intestinal cancer in Crohn¡¯s disease, including both colon and small bowel sites. In Crohn¡¯s disease, evidence suggests that detection of colorectal cancer may be delayed with a worse prognosis. Some risk factors for cancer in Crohn¡¯s disease include the extent of inflammatory change within the colon and the presence of bypassed or excluded segments, including rectal ¡°stump¡± cancer. In addition, the risk for other types of intestinal neoplasms may be increased in Crohn¡¯s disease, including lymphoma and carcinoid tumors. Earlier detection of colorectal cancer based on colonoscopy screening and surveillance may be achieved but, to date, this has not translated into a positive survival benefit. Moreover, newer staining methods and evolving micro-endoscopic techniques show promise, but have not significantly altered management. Future research should focus on development of molecular or other bio-markers that might predict future dysplasia or cancer development in Crohn¡¯s disease.
%K Colon cancer
%K Crohn¡¯s disease
%K Surveillance
%K Small bowel cancer
%U http://www.wjgnet.com/1007-9327/full/v14/i12/1810.htm