%0 Journal Article
%T Contrast-enhanced intraoperative ultrasonography equipped with late Kupffer-phase image obtained by sonazoid in patients with colorectal liver metastases
%A Hiroshi Nakano
%A Yasuo Ishida
%A Toshiyuki Hatakeyama
%A Kazuma Sakuraba
%A Masahiro Hayashi
%A Osamu Sakurai
%A Kiyoshi Hataya
%J World Journal of Gastroenterology
%D 2008
%I Baishideng Publishing Group Co. Limited
%X AIM: To find occult metastases during hepatectomy in patients with colorectal cancer liver metastases (CRCLM), contrast-enhanced intraoperative ultrasonography (CE-IOUS) was performed using a new microbubble agent, sonazoid, which provides a parenchyma-specific contrast image based on its accumulation in the Kupffer cells.METHODS: Eight patients with CRCLM underwent CE-IOUS using sonazoid before hepatectomy. The liver was investigated during a late Kupffer-phase imaging, which is a valuable characteristic of sonazoid.RESULTS: CE-IOUS using sonazoid provided the early vascular- and sinusoidal-phase images for10 min followed by the late Kupffer-phase image up to 30 min after the injection of sonazoid. IOUS did not provide new findings of metastatic lesion in the 8 patients. However, during the late Kupffer-phase image of sonazoid, a metastatic lesion was newly found in two of the 8 patients. These newly detected lesions were removed by an additional hepatectomy and histopathologically diagnosed as a metastasis.CONCLUSION: CE-IOUS using sonazoid can allow surgeons to investigate the whole liver with enough time and to find new metastases intraoperatively.
%K Contrast-enhanced intraoperative ultrasonography
%K Late Kupffer-phase image
%K Sonazoid
%K Colorectal cancer liver metastases
%K Occult hepatic lesions
%U http://www.wjgnet.com/1007-9327/full/v14/i20/3207.htm