%0 Journal Article
%T Relationship and significance between anti--glycoproteinI antibodies and platelet activation state in patients with ulcerative colitis
%A Yan-Hang Gao
%A Pu-Jun Gao
%A Chun-Guang Wang
%A Xiao-Cong Wang
%A Yun-Feng Piao
%J World Journal of Gastroenterology
%D 2008
%I Baishideng Publishing Group Co. Limited
%X AIM: To study the relationship between anti-¦Â2-glycoprotein I (a¦Â2GPI) antibodies and platelet activation state in patients with ulcerative colitis (UC) and its significance.METHODS: Peripheral blood samples were collected from 56 UC patients (34 males and 22 females, aged 43.5 years, range 21-66 years), including 36 at active stage and 20 at remission stage, and 25 sex-and age-matched controls. The level of a¦Â2GPI was measured by ELISA. The platelet activation markers, platelet activation complex-I (PAC-I) and P-selectin (CD62P) were detected by flow cytometry.RESULTS: The A value for IgG a¦Â2GPI in the active UC group was 0.61 ¡À 0.13, significantly higher than that in the remittent UC and control groups (0.50 ¡À 0.13 and 0.22 ¡À 0.14, P < 0.01). There was a significant difference between the two groups (P < 0.01). The A value for IgM a¦Â2GPI in the active and remittent UC groups was 0.43 ¡À 0.13 and 0.38 ¡À 0.12, significantly higher than that in the control group (0.20 ¡À 0.12, P < 0.01). However, there was no significant difference between the two groups (P > 0.05). The PAC-I positive rate for the active and remittent UC groups was 30.6% ¡À 7.6% and 19.6% ¡À 7.8% respectively, significantly higher than that for the control group (6.3% ¡À 1.7%, P < 0.01). There was a significant difference between the two groups (P < 0.01). The CD62P positive rate for the active and remittent UC groups was 45.0% ¡À 8.8% and 31.9% ¡À 7.8% respectively, significantly higher than that for the control group (9.2% ¡À 2.7%, P < 0.01). There was a significant difference between the two groups (P < 0.01). In the active UC group, the more severe the state of illness was, the higher the A value for IgG a¦Â2GPI was, and the positive rate for PAC-I and CD62P was positively correlated with the state of illness (Fa¦Â2GPI = 3.679, P < 0.05; FPAC-I (%) = 5.346, P < 0.01; and FCD62P (%) = 5. 418, P < 0.01). Meanwhile, in the same state of illness, the A value for IgG a¦Â2GPI was positively correlated to the positive rates for PAC-I and CD62P.CONCLUSION: a¦Â2GPI level, platelet activation state and their relationship of them are closely correlated with the pathogenesis and development of UC.
%K ¦Â2-glycoproteinI
%K Anti-¦Â2-glycoproteinI antibodies
%K Ulcerative colitis
%K Platelet activation
%K Hypercoagulation
%U http://www.wjgnet.com/1007-9327/full/v14/i5/771.htm