%0 Journal Article
%T Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats
%A Jun-Ho La
%A Tae-Sik Sung
%A Hyun-Ju Kim
%A Tae-Wan Kim
%A Tong Mook Kang
%A Il-Suk Yang
%J World Journal of Gastroenterology
%D 2008
%I Baishideng Publishing Group Co. Limited
%X AIM: To investigate whether peripheral corticotropin releasing hormone (CRH), which is up-regulated in intestinal inflammation, mediates the post-inflammatory visceral hypersensitivity in a rat model of colitis.METHODS: We measured mucosal myeloperoxidase (MPO) activity as a marker of inflammation, plasma CRH level, and abdominal withdrawal reflex (AWR) to colorectal distension as a visceral nociceptive response at 2, 7 and 14 d after the induction of colitis with 4% acetic acid.RESULTS: Colonic inflammation, quantified by MPO activity, significantly increased on d 2 and subsided thereafter, which indicated a resolution of inflammation within 7 d. On the contrary, plasma CRH level and AWR score were increased on d 2, remained high on d 7, and returned to control level on d 14. Intraperitoneal injection of a CRH antagonist, astressin (30 ¦Ìg/kg), significantly attenuated the post-inflammatory visceral hypersensitivity on d 7. Furthermore, intraperitoneal administration of CRH (3 and 10 ¦Ìg/kg) mimicked the post-inflammatory visceral hypersensitivity in naive rats.CONCLUSION: These results suggest that increased peripheral CRH mediates the enhanced visceral nociception in rats recovered from experimental colitis.
%K Corticotropin releasing hormone
%K Visceral hypersensitivity
%K Colitis
%U http://www.wjgnet.com/1007-9327/full/v14/i5/731.htm