%0 Journal Article
%T Vogel and Motulsky's human genetics--problems and approaches
%A Madhuri Kango-Singh
%J Human Genomics
%D 2010
%I BioMed Central
%R 10.1186/1479-7364-5-1-73
%X Human genetics is both a fundamental and an applied science. This makes it a complex and perhaps difficult proposition for writing text books, in that a cogent text would require the expertise of cytogeneticists, epidemiologists, population geneticists, physicians, human and medical geneticists, molecular biologists, computational biologists, etc. Vogel and Motulsky themselves wrote and edited the three earlier editions of this book, which is widely regarded as a key reference and textbook in the area of human and medical genetics. During the production of the fourth edition of this book, a new editorial team was assembled. Michael Speicher (Medical University of Graz, Austria), Stylianos Antonarakis (University of Geneva Medical School, Switzerland) and Arno Motulsky (University of Washington School of Medicine, USA) have done an excellent job as editors. They have extended, revised and added many of the new insights into the genetic basis of development and function in human health and disease that have emerged in the ten years since the publication of the third edition.Unlike the earlier editions, all chapters in this edition were written by renowned geneticists (including the editors) who are specialists/experts in the topic discussed in each chapter, thus lending a unique insight to each chapter. The book starts out with an update on the history of human genetics, followed by a discussion of the human genome sequence and variation. The chapter on chromosomes elegantly links the classical ideas and techniques of cytogenetic analysis to the modern techniques of detecting karyotypic abnormalities (structural or numerical) associated with human chromosomes (like fibre-fluorescence in situ hybridisation [FISH]- and array-based methods). Another chapter describes the currently popular high-throughput 'omics' approaches.The next five chapters are dedicated to introducing the reader to Mendelian genetics as applied to the inheritance of genetic traits in humans. This i
%U http://www.humgenomics.com/content/5/1/73