%0 Journal Article
%T New enamine derivatives of lapachol and biological activity
%A OLIVEIRA MAILCAR F.
%A LEMOS TELMA L.G.
%A MATTOS MARCOS C. DE
%A SEGUNDO TACIANA A.
%J Anais da Academia Brasileira de Ci¨ºncias
%D 2002
%I Academia Brasileira de Ci¨ºncias
%X A convenient synthesis of the new enamine derivatives 2-(4-morpholinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione, 2-(1-piperidinyl)-3-(3-methyl-2-butenyl)-1,4-naphtalenedione and 2-(1-pyrrolidinyl)-3-(3-methyl-2-butenyl)-1,4-naphthalenedione was carried out from natural 2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthalenedione (lapachol) and morpholine, piperidine and pyrrolidine. The structures of the products were established mainly by NMR analysis, including 2D experiments. Biological activities of these products were evaluated against Artemia salina, Aedes aegypti and cytotoxicity using A549 human breast cells.
%K lapachol
%K enamine derivatives
%K biological activities
%U http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652002000200004