%0 Journal Article
%T SYNTHESIS AND ANTICONVULSANT ACTIVITY OF SOME 2-PYRAZOLINES DERIVED FROM CHALCONES
%A Bedia KO£¿Y£¿£¿£¿T KAYMAK£¿IO£¿LU
%A El£¿in E. ORU£¿ EMRE
%A Nagihan BEYHAN
%A Hale Z. TOKLU
%J Anadolu University Journal of Science and Technology - C. Life Sciences and Biotechnology
%D 2011
%I Anadolu University
%X In the present study, a series of chalcones were prepared by Claisen Schmidt condensation as starting compounds and 2-pyrazoline derivatives have been synthesized by the reaction of chalcones with thiosemicarbazide. Their structures have been confirmed by IR, 1H-NMR, mass spectral data and elemental analysis. These synthesized 2-pyrazoline compounds have been tested in vivo anticonvulsant activity by using pentylenetetrazole (PTZ) induced seizure and maximal electroshock (MES) seizure tests at a dose of 50 mg/kg. None of the compounds have in vivo anticonvulsant properties in PTZ test whereas some compounds showed in vivo anticonvulsant activity in MES test. Therefore, 2-pyrazoline compounds have a promising in vivo anticonvulsant activity especially on generalized absence seizures.
%K Chalcones
%K 2-Pyrazolines
%K Thiocarbamide
%K Anticonvulsant activity
%U http://btd.anadolu.edu.tr/index.php/BTDC/article/viewFile/33/57