%0 Journal Article
%T Transarterial chemoembolization as initial treatment for unresectable hepatocellular carcinoma in southern China
%A Ming Shi
%A Ji-An Chen
%A Xiao-Jun Lin
%A Rong-Ping Guo
%A Yun-Fei Yuan
%A Min-Shan Chen
%A Ya-Qi Zhang
%A Jin-Qing Li
%J World Journal of Gastroenterology
%D 2010
%I Baishideng Publishing Group Co. Limited
%X AIM: To identify prognostic factors from pretreatment variables of the initial transarterial chemoembolization (TACE) procedure in unresectable hepatocellular carcinoma (HCC).METHODS: One thousand and five hundred and sixty-nine patients with unresectable HCC underwent TACE as initial treatment were retrospectively studied. Pretreatment variables of the initial TACE procedure with a P value less than 0.05 by univariate analysis were subjected to Cox proportional hazards model.RESULTS: The median overall survival time and 1-, 5-, 10-year survival rates were 10.37 mo, 47%, 10%, and 7%, respectively. A Cox proportional hazard model showed that 8 pretreatment factors of regional lymph nodes metastasis, Child-Pugh class, macrovascular invasion, greatest dimension, ¦Á-fetoprotein (AFP), Hepatitis virus B, tumor capsule, and nodules were independent prognostic factors. Patients with multimodality therapy have better survival than those with TACE treatment only.CONCLUSION: Tumor status, hepatic function reserve, AFP, and hepatitis virus B status were independent prognostic factors for unresectable HCC. Distant metastasis might not be a contraindication to TACE. Multimodality therapy might improve survival.
%K Hepatocellular carcinoma
%K Transarterial chemoembolization
%K Palliative treatment
%K Prognosis
%U http://www.wjgnet.com/1007-9327/full/v16/i2/264.htm