%0 Journal Article
%T Etiological and clinicopathologic characteristics of intrahepatic cholangiocarcinoma in young patients
%A Hua-Bang Zhou
%A Hui Wang
%A Dong-Xun Zhou
%A Hao Wang
%A Qing Wang
%A Shan-Shan Zou
%A He-Ping Hu
%J World Journal of Gastroenterology
%D 2010
%I Baishideng Publishing Group Co. Limited
%X AIM: To investigate the prevalence, risk factors, and clinicopathologic characteristics of intrahepatic cholangiocarcinoma (ICC) in young patients.METHODS: A retrospective analysis was performed in ICC patients referred to the Eastern Hepatobiliary Surgery Hospital in Shanghai, China. Among 317 consecutively enrolled patients, 40 patients were aged ¡Ü 40 years (12.61%). We compared the risk factors and clinicopathologic characteristics of these patients (group I: n = 40) with those aged > 40 years (group II: n = 277).RESULTS: Group I had distinct features compared with group II, including a low frequency of hepatolithiasis (P = 0.000); a high positive rate of serum hepatitis B surface antigen (P = 0.000) and hepatitis B virus (HBV)-associated cirrhosis (P = 0.038); a high frequency of ¦Á-fetoprotein (> 400 ¦Ìg/L) (P = 0.011); a low frequency of carbohydrate antigen 19-9 (> 37 U/mL) (P = 0.017); and a high frequency of liver histological inflammation (P = 0.002). Although there was no significant difference between the two groups in regards to hepatic schistosomiasis, alcohol-associated cirrhosis and cirrhosis due to other causes (P > 0.05), they only occurred in the elderly group.CONCLUSION: The risk factors are significantly different between young and elderly ICC patients. HBV and HBV-associated cirrhosis are the most important risk factors for young ICC patients.
%K Intrahepatic cholangiocarcinoma
%K Young patients
%K Clinicopathologic features
%K Hepatitis B virus
%K Risk factor
%U http://www.wjgnet.com/1007-9327/full/v16/i7/881.htm