%0 Journal Article
%T An antioxidant resveratrol significantly enhanced replication of hepatitis C virus
%A Mitsuyasu Nakamura
%A Hidetsugu Saito
%A Masanori Ikeda
%A Ryota Hokari
%A Nobuyuki Kato
%A Toshifumi Hibi
%A Soichiro Miura
%J World Journal of Gastroenterology
%D 2010
%I Baishideng Publishing Group Co. Limited
%X AIM: To elucidate the effect of antioxidants, resveratrol (RVT) and astaxanthin (AXN), on hepatitis C virus (HCV) replication.METHODS: We investigated the effect of recent popular antioxidant supplements on replication of the HCV replicon system OR6. RVT is a strong antioxidant and a kind of polyphenol that inhibits replication of various viruses. AXN is also a strong antioxidant. The replication of HCV RNA was assessed by the luciferase reporter assay. An additive effect of antioxidants on antiviral effects of interferon (IFN) and ribavirin (RBV) was investigated.RESULTS: This is the first report to investigate the effect of RVT and AXN on HCV replication. In contrast to other reported viruses, RVT significantly enhanced HCV RNA replication. Vitamin E also enhanced HCV RNA replication as reported previously, although AXN didnot affect replication. IFN and RBV significantly reduced HCV RNA replication, but these effects were dose-dependently hampered and attenuated by the addition of RVT. AXN didnot affect antiviral effects of IFN or RBV.CONCLUSION: These results suggested that RVT is not suitable as an antioxidant therapy for chronic hepatitis C.
%K Replicon system
%K Luciferase assay
%K Ribavirin
%K Interferon
%K Polyphenol
%K Astaxanthin
%U http://www.wjgnet.com/1007-9327/full/v16/i2/184.htm