%0 Journal Article
%T Short stature is an independent risk marker for mortality and incident coronary heart disease only in women: a structural relationship?
%A Altan Onat
%A Ender £¿rnek
%A G¨¹nay Can
%A G£¿khan £¿i£¿ek
%J Anadolu Kardiyoloji Dergisi
%D 2012
%I Aves Yayincilik
%X Objective: We evaluated the associations of short stature with coronary heart disease (CHD) risk or overall mortality, which vary with sex and ethnicity/race. Methods: Such associations were studied prospectively at a mean 13.5-years¡¯ follow-up in a population-based sample of 3394 Turkish adults (mean age 44¡À11 years) using Cox proportional hazards models. Covariates of height were sought in sex-specific tertiles.Results: Height averaged 162.7¡À6.5 cm. Age-adjusted estimated marginal means for serum triglycerides, C-reactive protein and complement C3 in women (but not men) were significantly higher with decreasing height tertiles. In sex- and age-adjusted models, height was associated in men with neither incident CHD, nor death. In women, 1-SD increment (6.5 cm) in height only tended to marginal inverse association with CHD, but predicted significantly all-cause death (HR 0.83, 95% CI 0.59-0.98); HR attenuated only marginally after further adjustment for family income bracket, smoking status, alcohol usage, systolic blood pressure, serum high-density lipoprotein (HDL)- and non HDL-cholesterol. A threshold below 160 cm of female height doubled the adjusted risk of death compared to taller women.Conclusion: In contrast to men, short stature in Turkish women tends to be an independent risk marker for CHD, and height below 160 cm is a strong marker of death. Gender-specific early-life influences enhancing pro-inflammatory state may affect death and future CHD.
%K Body height
%K coronary heart disease
%K epidemiology
%K gender difference
%K mortality
%K risk factors
%K regression analysis
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