%0 Journal Article
%T Association between Helicobacter pylori seropositivity and digestive tract cancers
%A I-Chen Wu
%A Deng-Chyang Wu
%A Fang-Jung Yu
%A Jaw-Yuan Wang
%A Chao-Hung Kuo
%A Sheau-Fang Yang
%A Chao-Ling Wang
%A Ming-Tsang Wu
%J World Journal of Gastroenterology
%D 2009
%I Baishideng Publishing Group Co. Limited
%X AIM: To explore the role of Helicobacter pylori (H pylori) infection on the risk of digestive tract cancers.METHODS: In total, 199 oral squamous-cell carcinoma (SCC), 317 esophageal SCC, 196 gastric cardia and non-cardia adenocarcinoma and 240 colon adenocarcinoma patients were recruited for serum tests of H pylori infection. Two hospital- and one community-based control groups were used for the comparisons. H pylori seropositivity was determined by an enzyme linked immunosorbent assay method against H pylori IgG.RESULTS: Presence of H pylori infection was significantly inversely associated with esophageal SCC [adjusted odds ratio (AOR): 0.315-0.472, all P-value < 0.05] but positively associated with gastric adenocarcinoma (both cardia and non-cardia) (AOR: 1.636-3.060, all P-value < 0.05) in comparison to the three control groups. Similar results were not found in cancers of the oral cavity and colon.CONCLUSION: Our findings support the finding that H pylori seropositivity is inversely associated with esophageal SCC risk, but increases the risk of gastric cardia adenocarcinoma.
%K Helicobacter pylori infection
%K Oral cancer
%K Esophageal squamous cell carcinoma
%K Gastric cardia adenocarcinoma
%K Colon cancer
%U http://www.wjgnet.com/1007-9327/full/v15/i43/5465.htm