%0 Journal Article
%T CD74 in antigen presentation, inflammation, and cancers of the gastrointestinal tract
%A Ellen J Beswick
%A Victor E Reyes
%J World Journal of Gastroenterology
%D 2009
%I Baishideng Publishing Group Co. Limited
%X CD74 is a protein whose initial role in antigen presentation was recognized two decades ago. Recent studies have revealed that it has additional functions as a receptor for macrophage migration inhibitory factor and as a receptor for an important human pathogen, Helicobacter pylori (H pylori). The role of CD74 as a receptor is important because after binding of migration inhibitory factor or H pylori, NF-¦ĘB and Erk1/2 activation occurs, along with the induction of proinflammatory cytokine secretion. This review provides an up-to-date account of the functions of CD74 and how it might be involved in inflammation and cancer within the gastrointestinal tract.
%K CD74
%K Invariant chain
%K Cancer
%K Inflammation
%K Helicobacter pylori
%K Gastrointestinal tract
%U http://www.wjgnet.com/1007-9327/full/v15/i23/2855.htm