%0 Journal Article
%T Comparison of health-related quality of life measures in chronic obstructive pulmonary disease
%A A Simon Pickard
%A Yoojung Yang
%A Todd A Lee
%J Health and Quality of Life Outcomes
%D 2011
%I BioMed Central
%R 10.1186/1477-7525-9-26
%X We analyzed data collected from 120 COPD patients in a Veterans Affairs hospital. Patients self-completed two generic HRQL measures (EQ-5D and SF-36) and the disease-specific SGRQ. The ability of the summary scores of these HRQL measures to discriminate COPD disease severity based on Global Obstructive Lung Disease (GOLD) stage was assessed using relative efficiency ratios (REs). Strength of correlation was used to further evaluate associations between clinical and HRQL measures.Mean total scores for PCS-36, EQ-VAS and SGRQ were significantly lower for the more severe stages of COPD (p < 0.05). Using SGRQ total score as reference, the summary scores of the generic measures (PCS-36, MCS-36, EQ index, and EQ-VAS) all had REs of <1. SGRQ exhibited a stronger correlation with clinical measures than the generic summary scores. For instance, SGRQ was moderately correlated with FEV1 (r = 0.43), while generic summary scores had trivial levels of correlation with FEV1 (r < 0.2).The SGRQ demonstrated greater ability to discriminate among different levels of severity stages of COPD than generic measures of health, suggestive that SGRQ may provide COPD studies with greater statistical power than EQ-5D and SF-36 summary scores to capture meaningful differences in clinical severity.Chronic obstructive pulmonary disease (COPD) is a leading cause of death worldwide and is associated with a high burden of illness [1], particularly in terms of health-related quality of life (HRQL). COPD is characterized by airflow obstruction that is not fully reversible and symptoms such as dyspnea, sputum production, and chronic cough [2]. Airflow limitation is usually progressive; thus daily activities can become very difficult as the condition gradually worsens. Consequently, the burden of COPD on HRQL disease tends to increase with COPD severity [3-6].HRQL is inherently subjective, involving patient self-assessment of multiple dimensions of health that often are not strongly correlated with clin
%K respiratory disease
%K quality of life
%K COPD
%K health status
%K EQ-5D
%U http://www.hqlo.com/content/9/1/26