%0 Journal Article
%T Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics
%A Jose Perea
%A Edurne Alvaro
%A Yolanda Rodr¨ªguez
%A Cristina Gravalos
%A Eva S¨¢nchez-Tom¨¦
%A Barbara Rivera
%A Francisco Colina
%A Pablo Carbonell
%A Rogelio Gonz¨¢lez-Sarmiento
%A Manuel Hidalgo
%A Miguel Urioste
%J World Journal of Gastroenterology
%D 2010
%I Baishideng Publishing Group Co. Limited
%X AIM: To characterize clinicopathological and familial features of early-onset colorectal cancer (CRC) and compare features of tumors with and without microsatellite instability (MSI).METHODS: Forty-five patients with CRC aged 45 or younger were included in the study. Clinical information, a three-generation family history, and tumor samples were obtained. MSI status was analyzed and mismatch repair genes were examined in the MSI families. Tumors were included in a tissue microarray and an immunohistochemical study was carried out with a panel of selected antibodies.RESULTS: Early onset CRC is characterized by advanced stage at diagnosis, right colon location, low-grade of differentiation, mucin production, and presence of polyps. Hereditary forms represent at least 21% of cases. Eighty-one percent of patients who died during follow-up showed a lack of expression of cyclin E, which could be a marker of poor prognosis. ¦Â-catenin expression was normal in a high percentage of tumors.CONCLUSION: Early-onset CRC has an important familial component, with a high proportion of tumors showing microsatellite stable. Cyclin E might be a poor prognosis factor.
%K Early onset colorectal cancer
%K Microsatellite instability
%K Lynch syndrome
%K Microsatellite stable colorectal cancer
%U http://www.wjgnet.com/1007-9327/full/v16/i29/3697.htm