%0 Journal Article
%T Association of Fas/Apo1 gene promoter (-670 A/G) polymorphism in Tunisian patients with IBD
%A Walid Ben Aleya
%A Imen Sfar
%A Leila Mouelhi
%A Houda Aouadi
%A Mouna Makhlouf
%A Salwa Ayed-Jendoubi
%A Samira Matri
%A Azza Filali
%A Taoufik Najjar
%A Taeib Ben Abdallah
%A Khaled Ayed
%A Yousr Gorgi
%J World Journal of Gastroenterology
%D 2009
%I Baishideng Publishing Group Co. Limited
%X AIM: To detect a possible association between the polymorphism of the (-670 A/G) Fas/Apo1 gene promoter and susceptibility to Crohn¡¯s disease (CD) and ulcerative colitis (UC) in the Tunisian population.METHODS: The (-670 A/G) Fas polymorphism was analyzed in 105 patients with CD, 59 patients with UC, and 100 controls using the polymerase chain reaction restriction fragment length polymorphism method.RESULTS: Significantly lower frequencies of the Fas -670 A allele and A/A homozygous individuals were observed in CD and UC patients when compared with controls. Analysis of (-670 A/G) Fas polymorphism with respect to sex in CD and UC showed a significant difference in A/A genotypes between female patients and controls (P corrected = 0.004 in CD patients and P corrected = 0.02 in UC patients, respectively). Analysis also showed a statistically significant association between genotype AA of the (-670 A/G) polymorphism and the ileum localization of the lesions (P corrected = 0.048) and between genotype GG and the colon localization (P corrected = 0.009). The analysis of inflammatory bowel disease patients according to clinical behavior revealed no difference.CONCLUSION: Fas-670 polymorphism was associated with the development of CD and UC in the Tunisian population.
%K Fas/Apo1
%K Gene polymorphisms
%K Inflammatory bowel disease
%K Crohn¡¯s disease
%K Ulcerative colitis
%U http://www.wjgnet.com/1007-9327/full/v15/i29/3643.htm