%0 Journal Article
%T Shear wave velocity is a useful marker for managing nonalcoholic steatohepatitis
%A Akihiko Osaki
%A Tomoyuki Kubota
%A Takeshi Suda
%A Masato Igarashi
%A Keisuke Nagasaki
%A Atsunori Tsuchiya
%A Masahiko Yano
%A Yasushi Tamura
%A Masaaki Takamura
%A Hirokazu Kawai
%A Satoshi Yamagiwa
%A Toru Kikuchi
%A Minoru Nomoto
%A Yutaka Aoyagi
%J World Journal of Gastroenterology
%D 2010
%I Baishideng Publishing Group Co. Limited
%X AIM: To investigate whether a noninvasive measurement of tissue strain has a potential usefulness for management of nonalcoholic steatohepatitis (NASH).METHODS: In total 26 patients, 23 NASHs and 3 normal controls were enrolled in this study. NASH was staged based on Brunt criterion. At a region of interest (ROI), a shear wave was evoked by implementing an acoustic radiation force impulse (ARFI), and the propagation velocity was quantified.RESULTS: Shear wave velocity (SWV) could be reproducibly quantified at all ROIs in all subjects except for 4 NASH cases, in which a reliable SWV value was not calculated at several ROIs. An average SWV of 1.34 ¡À 0.26 m/s in fibrous stage 0-1 was significantly slower than 2.20 ¡À 0.74 m/s and 2.90 ¡À 1.01 m/s in stages 3 and 4, respectively, but was not significantly different from 1.79 ¡À 0.78 m/s in stage 2. When a cutoff value was set at 1.47 m/s, receiver operating characteristic analysis showed significance to dissociate stages 3 and 4 from stage 0-1 (P = 0.0092) with sensitivity, specificity and area under curve of 100%, 75% and 94.2%, respectively. In addition, the correlation between SWV and hyaluronic acid was significant (P < 0.0001), while a tendency toward negative correlation was observed with serum albumin (P = 0.053).CONCLUSION: The clinical implementation of ARFI provides noninvasive repeated evaluations of liver stiffness at an arbitrary position, which has the potential to shed new light on NASH management.
%K Nonalcoholic steatohepatitis
%K Ultrasound
%K Liver stiffness measurement
%K Shear wave velocity
%K Acoustic radiation force impulse
%U http://www.wjgnet.com/1007-9327/full/v16/i23/2918.htm