%0 Journal Article
%T Screening test for anti-Helicobacter pylori activity of traditional Chinese herbal medicines
%A Feng Ma
%A Ye Chen
%A Jing Li
%A He-Ping Qing
%A Ji-De Wang
%A Ya-Li Zhang
%A Bei-Guo Long
%A Yang Bai
%J World Journal of Gastroenterology
%D 2010
%I Baishideng Publishing Group Co. Limited
%X AIM: To evaluate the anti-Helicobacter pylori (H. pylori) activity of 50 traditional Chinese herbal medicines in order to provide the primary evidence for their use in clinical practice.METHODS: A susceptibility test of water extract from 50 selected traditional Chinese herbal medicines for in vitro H. pylori Sydney strain 1 was performed with broth dilution method. Anti-H. pylori activity of the selected Chinese herbal medicines was evaluated according to their minimum inhibitory concentration (MIC).RESULTS: The water extract from Rhizoma Coptidis, Radix Scutellariae and Radix isatidis could significantly inhibit the H. pylori activity with their MIC less than 7.8 mg/mL, suggesting that traditional Chinese herbal medicines have anti-inflammatory and antibacterial effects and can thus be used in treatment of H. pylori infection.CONCLUSION: Rhizoma Coptidis, Radix Scutellariae and Radix isatidis are the potential sources for the synthesis of new drugs against H. pylori.
%K Chinese herbal medicines
%K Helicobacter pylori
%K Minimum inhibitory concentration
%K Gastric
%K Oral
%U http://www.wjgnet.com/1007-9327/full/v16/i44/5629.htm