%0 Journal Article
%T Alkaline phosphatase predicts relapse in chronic hepatitis C patients with end-of-treatment response
%A Gerd Bodlaj
%A Rainer Hubmann
%A Karim Saleh
%A Tatjana Stojakovic
%A Georg Biesenbach
%A J£¿rg Berg
%J World Journal of Gastroenterology
%D 2010
%I Baishideng Publishing Group Co. Limited
%X AIM: To investigate relapse predictors in chronic hepatitis C (CHC) patients with end-of-treatment response (ETR), after pegylated interferon-¦Á (PegIFN-¦Á) and ribavirin treatment.METHODS: In a retrospective study we evaluated a spectrum of predictors of relapse after PegIFN-¦Á and ribavirin treatment in 86 CHC patients with ETR. Viral loads were determined with real-time reverse transcription polymerase chain reaction. Hepatitis C virus genotyping was performed by sequencing analysis. Patients with genotype 1 were treated for 48 wk with 180 ¦Ìg PegIFN-¦Á2a or 1.5 ¦Ìg/kg PegIFN-¦Á2b once weekly plus ribavirin at a dosage of 1000 mg/d for those under 75 kg or 1200 mg/d for those over 75 kg. Patients with genotypes 2 and 3 were treated for 24 wk with 180 ¦Ìg PegIFN-¦Á2a or 1.5 ¦Ìg/kg PegIFN-¦Á2b once weekly plus ribavirin at a dosage of 800 mg/d.RESULTS: In all ETR patients, binary logistic regression analysis identified absence of complete early virological response (cEVR) (OR 27.07, 95% CI: 3.09-237.26, P < 0.005), serum alkaline phosphatase (ALP) levels prior to therapy < 75 U/L (OR: 6.16, 95% CI: 2.1-18.03, P < 0.001) and body mass index > 26 kg/m2 (OR: 8.27, 95% CI: 2.22-30.84, P < 0.005) as independent predictors of relapse. When cEVR patients were analyzed exclusively, ALP prior to therapy < 75 U/L remained the only predictor of relapse.CONCLUSION: Lower levels of ALP prior to, during and after therapy seem to be associated with a higher risk of relapse in CHC patients with ETR.
%K Alkaline phosphatase
%K Chronic hepatitis C
%K Pegylated interferon
%K Predictor
%K Relapse
%U http://www.wjgnet.com/1007-9327/full/v16/i19/2407.htm