%0 Journal Article
%T Human papillomavirus DNA and P16 expression in concurrent esophageal and gastric cardia cancers
%A Guang-Cheng Ding
%A Jing-Li Ren
%A Fu-Bao Chang
%A Ji-Lin Li
%A Ling Yuan
%A Xin Song
%A Sheng-Li Zhou
%A Tao Guo
%A Zong-Min Fan
%A Yi Zeng
%A Li-Dong Wang
%J World Journal of Gastroenterology
%D 2010
%I Baishideng Publishing Group Co. Limited
%X AIM: To investigate the relationship between human papillomavirus (HPV) infection and concurrent esophagus and gastric cardia cancer from the same patient (CC) and examine the significance of P16INK4A protein expression.METHODS: Polymerase chain reaction was used to detect the presence of HPV type16 (HPV16). The expression of P16INK4A protein was detected using immunohistochemistry.RESULTS: Among the CC specimens, HPV16-DNA was found in eight cases of esophageal squamous cell carcinoma (ESCC) and five cases of gastric cardia adenocarcinoma (GCA), respectively (47% vs 29%), and two of both ESCC and GCA. P16INK4A was highly expressed in both ESCC and GCA. In the HPV-associated positive CC, higher P16INK4A expression was observed in the GCA than in the ESCC (75% vs 25%, P < 0.05).CONCLUSION: HPV16 as a correlated risk factor may play an important role in the development of ESCC and GCA. P16INK4A may be a screening index in the HPV-associated carcinoma of gastric cardia.
%K Esophageal squamous cell carcinoma
%K Gastric cardia adenocarcinoma
%K Human papillomavirus
%K Polymerase chain reaction
%K Immunohistochemistry
%U http://www.wjgnet.com/1007-9327/full/v16/i46/5901.htm