%0 Journal Article
%T Clinical significance of serum expression of GRO¦Â in esophageal squamous cell carcinoma
%A Qiao-Mei Dong
%A Jin-Qiang Zhang
%A Qian Li
%A Jacqueline C Bracher
%J World Journal of Gastroenterology
%D 2011
%I Baishideng Publishing Group Co. Limited
%R 10.3748/wjg.v17.i21.2658
%X AIM: To determine the association between serum levels of growth-related gene product ¦Â (GRO¦Â) and clinical parameters in esophageal squamous cell carcinoma (ESCC). METHODS: Using enzyme-linked immunosorbent assay, serum GRO¦Â levels were measured in ESCC patients (n = 72) and healthy volunteers (n = 83). The association between serum levels of GRO¦Â and clinical parameters of ESCC was analyzed statistically. RESULTS: The serum GRO¦Â levels were much higher in ESCC patients than in healthy controls (median: 645 ng/L vs 269 ng/L, P < 0.05). Serum GRO¦Â levels were correlated positively with tumor size, lymph node metastasis, and tumor-node-metastasis (TNM) staging, but not with gender or the histological grade of tumors in ESCC patients. The sensitivity and specificity of the assay for serum GRO¦Â were 73.61% and 56.63%, respectively. CONCLUSION: GRO¦Â may function as an oncogene product and contribute to tumorigenesis and metastasis of ESCC.
%K GRO¦Â
%K Esophageal squamous cell carcinoma
%K Metastasis
%K Cytokine
%K Tumor markers
%U http://www.wjgnet.com/1007-9327/full/v17/i21/2658.htm