%0 Journal Article
%T Association between polymorphism rs6983267 and gastric cancer risk in Chinese population
%A Yi Guo
%A Jing Fang
%A Yan Liu
%A Hai-Hui Sheng
%A Xiao-Yan Zhang
%A Hai-Na Chai
%A Wei Jin
%A Ke-Hao Zhang
%A Chang-Qing Yang
%A Heng-Jun Gao
%J World Journal of Gastroenterology
%D 2011
%I Baishideng Publishing Group Co. Limited
%X AIM: To explore the association between single nucleotide polymorphisms (SNPs) at 8q24 and gastric cancer risk.METHODS: A case-control investigation including 212 gastric cancer patients and 377 healthy controls was conducted. The genotypes of SNPs (rs6983267, rs7008482 and rs10808555) were examined and established through polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Multivariate logistic regression models were used to evaluate the association between SNPs and gastric cancer.RESULTS: The genotype frequencies of rs6983267 in gastric cancer patients were obviously different from those in the control (P = 0.005). GT genotype of rs6983267 was associated with an increased risk of gastric cancer compared with GG genotype (adjusted odds ratio = 2.01, 95% confidence interval: 1.28-3.14). Further stratified analysis indicated that rs6983267 GT genotype facilitated the risk of gastric cancer of non-cardiac and intestinal type (OR: 2.638, 95% CI: 1.464-4.753; OR: 1.916, 95% CI: 1.166-3.150, respectively).CONCLUSION: This study demonstrates for the first time that rs6983267 is involved in susceptibility to gastric cancer, although further large-sample investigations are still needed.
%K Gastric cancer
%K Genetic susceptibility
%K Single nucleotide polymorphism
%K MYC
%K 8q24
%U http://www.wjgnet.com/1007-9327/full/v17/i13/1759.htm