%0 Journal Article
%T Linking the Tinnitus Questionnaire and the subjective Clinical Global Impression: Which differences are clinically important?
%A Ilya Adamchic
%A Peter A Tass
%A Berthold Langguth
%A Christian Hauptmann
%A Michael Koller
%A Martin Schecklmann
%A Florian Zeman
%A Michael Landgrebe
%J Health and Quality of Life Outcomes
%D 2012
%I BioMed Central
%R 10.1186/1477-7525-10-79
%X 757 patients with chronic tinnitus were pooled from the TRI database and the RESET study. An anchor-based approach using the Clinical Global Impression (CGI) scale and distributional approaches were used to estimate MCID. Receiver Operating Characteristic (ROC) curves were calculated to define optimal TQ change cutoffs discriminating between minimally changed and unchanged subjects.The relationship between TQ change scores and CGI ratings of change was good (r£¿=£¿0.52, p£¿<£¿0.05). Mean change scores associated with minimally better and minimally worse CGI categories were £¿6.65 and +2.72 respectively. According to the ROC method MCID for improvement was £¿5 points and for deterioration +1 points.Distribution and anchor-based methods yielded comparable results in identifying MCIDs. ¦¤TQ scores of £¿5 and +1 points were identified as the minimal clinically relevant change for improvement and worsening respectively. The asymmetry of the MCIDs for improvement and worsening may be related to expectation effects.
%K Tinnitus
%K Tinnitus questionnaire
%K Minimal clinically important difference
%K Clinical significance
%K Receiver operating characteristic
%U http://www.hqlo.com/content/10/1/79/abstract