%0 Journal Article
%T Low red blood cell levels of deglycating enzymes in colorectal cancer patients
%A Maria Notarnicola
%A Maria Gabriella Caruso
%A Valeria Tutino
%A Vito Guerra
%A Giovanni Misciagna
%J World Journal of Gastroenterology
%D 2011
%I Baishideng Publishing Group Co. Limited
%X AIM: To investigate Glyoxalase I and fructosamine-3-kinase (FN3K) activity in red blood cells from patients with colorectal adenomas and cancer.METHODS: Thirty three consecutive subjects with one or more histologically confirmed colorectal adenomatous polyps, 16 colorectal cancer patients and a group of 11 control subjects with normal colonoscopy were included in the study. Glyoxalase I and FN3K activities were measured in red blood cells using a spectrophotometric and radiometric assay, respectively.RESULTS: A significant reduction in both Glyoxalase I and FN3K activity was detected in patients with tumors compared to patients with adenomas and the controls. Erythrocyte Glyoxalase I activity in colorectal cancer was approximately 6 times lower than that detected in patients with adenoma (0.022 ¡À 0.01 mmol/min per milliliter vs 0.128 ¡À 0.19 mmol/min per milliliter of red blood cells, P = 0.003, Tukey¡¯s test). FN3K activity in red blood cells from patients with colon cancer was approximately 2 times lower than that detected in adenoma patients (19.55 ¡À 6.4 pmol/min per milliliter vs 38.6 ¡À 31.7 pmol/min per milliliter of red blood cells, P = 0.04, Tukey¡¯s test).CONCLUSION: These findings suggest that deglycating enzymes may be involved in the malignant transformation of colon mucosa.
%K Colorectal cancer
%K Enzymatic activity
%K Fructosamine-3-kinase
%K Glycation
%K Glyoxalase I
%U http://www.wjgnet.com/1007-9327/full/v17/i3/329.htm