%0 Journal Article
%T Evaluation of acoustic radiation force impulse imaging for determination of liver stiffness using transient elastography as a reference
%A Gerald Kircheis
%A Abdurrahman Sagir
%A Christoph Vogt
%A Stephan vom Dahl
%J World Journal of Gastroenterology
%D 2012
%I Baishideng Publishing Group Co. Limited
%R 10.3748/wjg.v18.i10.1077
%X AIM: To evaluate cut-off values and performance of acoustic radiation force impulse imaging (ARFI) using transient elastography [FibroScan  (FS)] as a reference. METHODS: Six hundred and six patients were enrolled in this study. All patients underwent liver stiffness measurement with FS (FS-LS) and ARFI (with shear wave velocity quantification; ARFI-SWV) and the performance of ARFI in comparison to FS was determined. Sixty-eight patients underwent liver biopsy. RESULTS: Significantly higher success rates for the determination of liver stiffness were found using ARFI as compared to FS [604/606 (99.7%) vs 482/606 (79.5%), P < 0.001]. ARFI-SWV correlated significantly with FS-LS (r = 0.920, P < 0.001). ARFI-SWV increased significantly with the stage of fibrosis (1.09 ¡À 0.13 m/s for patients with no significant fibrosis (FS-LS < 7.6 kPa); 1.46 ¡À 0.27 m/s for patients with significant liver fibrosis (7.6 < FS-LS ¡Ü 13.0 kPa); and 2.55 ¡À 0.77 m/s for patients with liver cirrhosis (FS-LS > 13.0 kPa)). ARFI-SWV cut-off values were identified for no significant fibrosis (1.29 m/s; sensitivity 91.4% and specificity 92.6%) and for liver cirrhosis (1.60 m/s; sensitivity 92.3% and specificity 96.5%). The optimal cut-off value for predicting liver fibrosis (F ¡Ý 2) was 1.32 m/s (sensitivity 87.0% and specificity 80.0%) and for liver cirrhosis (F4) 1.62 m/s (sensitivity 100% and specificity 85.7%), for patients who underwent liver biopsy. An excellent inter-and intraobserver reproducibility was observed for ARFI-SWV determinations. CONCLUSION: An ARFI-SWV cut-off value of 1.29 m/s seems to be optimal for patients with no significant liver fibrosis and 1.60 m/s for patients with liver cirrhosis.
%K Acoustic radiation force impulse imaging
%K Elastography
%K Fibroscan
%K Liver
%U http://www.wjgnet.com/1007-9327/full/v18/i10/1077.htm