%0 Journal Article
%T Clinical implication of 14-3-3 epsilon expression in gastric cancer
%A Mariana Ferreira Leal
%A Danielle Queiroz Calcagno
%A Samia Demachki
%A Paulo Pimentel Assump£¿£¿o
%J World Journal of Gastroenterology
%D 2012
%I Baishideng Publishing Group Co. Limited
%R 10.3748/wjg.v18.i13.1531
%X AIM: To evaluate for the first time the protein and mRNA expression of 14-3-3¦Å in gastric carcinogenesis. METHODS: 14-3-3¦Å protein expression was determined by western blotting, and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples. RESULTS: Authors observed a significant reduction of 14-3-3¦Å protein expression in gastric cancer (GC) samples compared to their matched non-neoplastic tissue. Reduced levels of 14-3-3¦Å were also associated with diffuse-type GC and early-onset of this pathology. Our data suggest that reduced 14-3-3¦Å may have a role in gastric carcinogenesis process. CONCLUSION: Our results reveal that the reduced 14-3-3¦Å expression in GC and investigation of 14-3-3¦Å interaction partners may help to elucidate the carcinogenesis process.
%K Gastric cancer
%K 14-3-3 epsilon
%K YWHAE
%K Gene expression
%K Protein expression
%U http://www.wjgnet.com/1007-9327/full/v18/i13/1531.htm