%0 Journal Article
%T Infliximab induces remission in cryptogenic multifocal ulcerous stenosing enteritis: First case
%A De Schepper Heiko
%A Macken Elisabeth
%A Van Marck Veerle
%A Spinhoven Maarten
%J World Journal of Gastroenterology
%D 2013
%I Baishideng Publishing Group Co. Limited
%R 10.3748/wjg.v19.i10.1661
%X We present the case of a 29-year-old patient with a history of abdominal pain and vomiting. Based on wireless video capsule findings he was previously diagnosed with ileal Crohn¡¯s disease at a different institution, although the clinical and radiological picture was not typical and the response to corticosteroids was poor. We performed a single-balloon enteroscopy showing a short, ulcerous stenosis 50 cm proximal from Bauhin¡¯s valve. The endoscopic and clinical histopathological findings were compatible with cryptogenic multifocal ulcerous stenosing enteritis (CMUSE). High dose corticosteroids were again started, without effect. The monoclonal tumor necrosis factor-¦Á (TNF-¦Á) antibody infliximab was added to the medical therapy. After induction therapy, both clinical and endoscopic amelioration was obtained. Larger case studies are needed to confirm the efficacy of TNF-¦Á inhibition in steroid refractory CMUSE.
%K Cryptogenic multifocal ulcerous stenosing enteritis
%K Infliximab
%K Stenosis
%K Intestinal ulceration
%K Inflammatory bowel disease
%U http://www.wjgnet.com/1007-9327/full/v19/i10/1661.htm