%0 Journal Article %T Management of type 2 diabetes mellitus in youth %A Vassilios Giampatzis %A Konstantinos Tziomalos %J World Journal of Diabetes %D 2012 %I Baishideng Publishing Group Co. Limited %R 10.4239/wjd.v3.i12.182 %X The rising rates of obesity in youth have concurrently led to an increase in the rates of type 2 diabetes mellitus (T2DM) in this age group. However, there are limited data on the efficacy of different antidiabetic agents in youth. In this context, the Treatment Options for Type 2 Diabetes in Adolescents and Youth trial recently reported that the majority of obese children and adolescents 10-17-years old with newly diagnosed T2DM (T2DM duration less than 2 years) could not achieve HbA1c levels < 8% for more than 1 year with metformin monotherapy, metformin plus rosiglitazone combination, or metformin and lifestyle changes. These findings suggest that, in the majority of youth with T2DM, tight long-term glycemic control with oral agents is an elusive goal and that most patients will require treatment with insulin within a few years of diagnosis to achieve HbA1c targets and reduce the risk of macro- and microvascular complications. Therefore, reducing the incidence of T2DM by preventing pediatric obesity through the implementation of lifestyle changes in the community should be the primary objective of healthcare systems. %K Type 2 diabetes mellitus %K Metformin %K Rosiglitazone %K Lifestyle changes %K Insulin %U http://www.wjgnet.com/1948-9358/full/v3/i12/182.htm