%0 Journal Article
%T Biochemical and cellular evidence of the benefit of a combination of cerium oxide nanoparticles and selenium to diabetic rats
%A Nazila Pourkhalili
%A Asieh Hosseini
%A Amir Nili-Ahmadabadi
%A Shokoufeh Hassani
%J World Journal of Diabetes
%D 2011
%I Baishideng Publishing Group Co. Limited
%R 10.4239/wjd.v2.i11.204
%X AIM: To study the combinative effects of nanocerium and selenium in a murine model of diabetes. METHODS: Cerium oxide (CeO2) nanoparticles (60 mg/kg per day) and sodium selenite (5 ¦̀mol/kg per day) alone or in combination, or the metal form of CeO2 (60 mg/kg) were administered for 2 wk by intraperitoneal injection to streptozotocin-induced diabetic rats. At the end of treatment blood was collected, liver tissue dissected and then oxidative stress markers, extent of energy depletion and lipid profile were evaluated. RESULTS: Antioxidant enzymes and high density lipoprotein decreased whereas oxidative stress, adenosine diphosphate/adenosine triphospahte levels, cholesterol, triglyceride and low density lipoprotein increased on induction of diabetes. All were improved by a combination of nanocerium and sodium selenite. There was a relative amelioration by CeO2 nanoparticles or sodium selenite alone, but the metal form of CeO2 showed no significant improvement. CONCLUSION: The combination of nanocerium and sodium selenite is more effective than either alone in improving diabetes-induced oxidative stress.
%K Diabetes
%K Oxidative stress
%K Cerium oxide nanoparticles
%K Sodium selenite
%K Nanotoxicology
%K Nanotechnology
%U http://www.wjgnet.com/1948-9358/full/v2/i11/204.htm