%0 Journal Article
%T Cytotoxicity and Structure-Activity Relationships of Xanthone Derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora towards Nine Human Cancer Cell Lines
%A Soek Sin Teh
%A Gwendoline Cheng Lian Ee
%A Siau Hui Mah
%A Yang Mooi Lim
%A Zuraini Ahmad
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18021985
%X The cytotoxic structure-activity relationships among a series of xanthone derivatives from Mesua beccariana, Mesua ferrea and Mesua congestiflora were studied. Eleven xanthone derivatives identified as mesuarianone ( 1), mesuasinone ( 2), mesuaferrin A ( 3), mesuaferrin B ( 4), mesuaferrin C ( 5), 6-deoxyjacareubin ( 6), caloxanthone C ( 7), macluraxanthone ( 8), 1,5-dihydroxyxanthone ( 9), tovopyrifolin C ( 10) and ¦Á-mangostin ( 11) were isolated from the three Mesua species. The human cancer cell lines tested were Raji, SNU-1, K562, LS-174T, SK-MEL-28, IMR-32, HeLa, Hep G2 and NCI-H23. Mesuaferrin A ( 3), macluraxanthone ( 8) and ¦Á-mangostin ( 11) showed strong cytotoxicities as they possess significant inhibitory effects against all the cell lines. The structure-activity relationship (SAR) study revealed that the diprenyl, dipyrano and prenylated pyrano substituent groups of the xanthone derivatives contributed towards the cytotoxicities.
%K cytotoxicity
%K Mesua beccariana
%K Mesua ferrea
%K Mesua congestiflora
%K structure-activity relationship
%K xanthones
%U http://www.mdpi.com/1420-3049/18/2/1985