%0 Journal Article
%T LOH-profiling by SNP-mapping in a case of multifocal head and neck cancer
%A Jens Pfeiffer
%A Wolfgang Maier
%A Gerd J Ridder
%A Karim Zaoui
%J World Journal of Clinical Oncology
%D 2012
%I Baishideng Publishing Group Co. Limited
%R 10.5306/wjco.v3.i2.24
%X AIM: To introduce an approach for the detection of putative genetic host factors that predispose patients to develop head and neck squamous cell carcinomas (HNSCC). METHODS: HNSCC most often result from the accumulation of somatic gene alterations found in tumor cells. A cancer-predisposing genetic background must be expected in individuals who develop multiple cancers, starting at an unexpectedly young age or with little carcinogen exposure. Genome-wide loss of heterozygosity (LOH) profiling by single nucleotide polymorphism microarray mapping was performed in a patient with a remarkable history of multifocal HNSCC. RESULTS: Regions of genomic deletions in germline DNA were identified on several chromosomes with a remarkable size between 1.6 Mb and 8.1 Mb (mega base-pair). No LOH was detected at the genomic location of the tumor suppressor gene P53. CONCLUSION: Specific patterns of germline DNA deletions may be responsible for susceptibility to HNSCC and should be further analyzed.
%K Genome-wide analysis
%K Head and neck cancer
%K Loss of heterozygosity
%K Multifocal cancer
%K Single nucleotide polymorphism microarray
%K Squamous cell carcinoma
%U http://www.wjgnet.com/2218-4333/full/v3/i2/24.htm