%0 Journal Article
%T Ikaros in B cell development and function
%A MacLean Sellars
%A Philippe Kastner
%A Susan Chan
%J World Journal of Biological Chemistry
%D 2011
%I Baishideng Publishing Group Co. Limited
%R 10.4331/wjbc.v2.i6.132
%X The zinc finger transcription factor, Ikaros, is a central regulator of hematopoiesis. It is required for the development of the earliest B cell progenitors and at later stages for VDJ recombination and B cell receptors expression. Mature B cells rely on Ikaros to set the activation threshold for various stimuli, and to choose the correct antibody isotype during class switch recombination. Thus, Ikaros contributes to nearly every level of B cell differentiation and function.
%K Ikaros
%K Hematopoiesis
%K Mature B cells
%U http://www.wjgnet.com/1949-8454/full/v2/i6/132.htm