%0 Journal Article
%T New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities
%A Carlos Barea
%A Adriana Pab¨®n
%A Silvia P¨¦rez-Silanes
%A Silvia Galiano
%A German Gonzalez
%A Antonio Monge
%A Eric Deharo
%A Ignacio Aldana
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18044718
%X Malaria and leishmaniasis are two of the World¡¯s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di- N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 ¦ÌM), while a cyclohexyl derivative (2.5 ¦ÌM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 ¦ÌM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R 7 position.
%K quinoxaline
%K 1
%K 4-di-N-oxide
%K leishmanicidal
%K antiplasmodial
%U http://www.mdpi.com/1420-3049/18/4/4718