%0 Journal Article
%T Synthesis of Esters of Ginsenoside Metabolite M1 and Their Cytotoxicity on MGC80-3 Cells
%A Wen-Fang Li
%A Li-Rong Chen
%A Xiao-Jie Gong
%A Zheng-Ning Li
%A Ke-Ke Li
%J Molecules
%D 2013
%I MDPI AG
%R 10.3390/molecules18043689
%X Monoesters of ginsenoside metabolite M1 at the 3-OH, 4-OH and 6-OH positions of the glucose moiety at M1 were synthesized via the reaction of M1 with acyl chloride, or acid- N,N'-diisopropylcarbodiimide in the presence of DMAP. Their structures were fully characterized by spectral methods. The cytotoxicity of these compounds against then MGC80-3 human gastric cancer cell line was also assessed. High inhibitory effects were found at a concentration of 100 ¦Ìg/mL.
%K ginsenoside
%K synthesis
%K cytotoxicity
%K MGC80-3
%U http://www.mdpi.com/1420-3049/18/4/3689